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KMID : 0377519910160010011
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Chung-Ang Journal of Medicine
1991 Volume.16 No. 1 p.11 ~ p.19
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Immunohistochemical Studies of Serotonin, Somatostation and Glucagon containing cells of the Colonic Adenocarcinoma
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Abstract
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Endocrine cells in 30 primary adenocarcinoma and in the non-neoplastic: mucosae of the colon were investigated immunohistochemically with antisera against serotonin and two kinds of peptide hormones.
The positive reaction of three endocrine cells is more frequently in left colon than that in right colon. Immunoreactive serotonin cells occurred most frequently and were distributed most densely in the carcinoma and in the non-neoplastic mucosa. In the non-neoplastic mucosa, fourteen of´ 30 cases (46.67%) with immunoreactive endocrine cells showed only one kind of´ such cell; serotonin in 9/30 (30%), somatostatin in 3/30 (10%) and glucagon in 2/30 (6.67%). Nine others (30%) each contained two kinds of´cells; serotonin and somatostatin in 5/39 (16.677o), serotonin and glucagon in 4/30 (13.3317o), and the remaining one case produced three kinds of´ immunoreactive gut hormones; serotonin somatOSatin and glucagon. In the neoplastic lesion, ten of 30 cases (33.31,7c) with immunoreactive endocrine cells showed only one kind of´ such cells; serotonin in 5/30 (16.67%), somatostatin in 2/30(6.67%) and glucagon in 3/30 (10%). Other 5 cases (16.67%) produced two kinds of immunoreactive t;ut hormones; serotonin and somatostatin in 4/30 (13.33%), serotonin and glucagon in 1/30 (3.337c).
Therefore, when the multipotential endodermal cells of mucosa in the colon transform into usual adenocarcinoma, tumor cells are frequently differentiated into the non-endocrine cell than the of endocrine type.
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